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KMID : 0032220230350040243
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Annals of Dermatology
2023 Volume.35 No. 4 p.243 ~ p.255
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The Immune Microenvironment in Basal Cell Carcinoma
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Catherine Zilberg
James Guy Lyons
Ruta Gupta
Diona Lee Damian
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Abstract
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The immune system plays a key role in the suppression and progression of basal cell carci- noma (BCC). The primary aetiological factor for BCC development is exposure to ultraviolet radiation (UVR) which, particularly in lighter Fitzpatrick skin types, leads to the accumula- tion of DNA damage. UVR has roles in the generation of an immunosuppressive environ- ment, facilitating cancer progression. Rates of BCC are elevated in immunosuppressed patients, and BCC may undergo spontaneous immune-mediated regression. Histologic and immunohistochemical profiling of BCCs consistently demonstrates the presence of an immune infiltrate and associated immune proteins. Early studies of immune checkpoint inhibitors reveal promising results in BCC. Therefore, the host immune system and tumor responses to it are important in BCC pathogenesis. Understanding these interactions will be beneficial for disease prognostication and therapeutic decisions.
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KEYWORD
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Basal cell, Carcinoma, Neoplasms, Skin neoplasms, Tumor-infiltrating lymphocytes
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